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Methotrexate and leflunomide

There is also evidence that administering leflunomide to patients with an incomplete response to methotrexate improves disease activity without triggering an excessive number of adverse events. This has been shown in both a small open study and a large randomized controlled trial. However, the approach remains controversial because of concerns expressed by regulatory
bodies that this combination presents an unacceptable risk of liver toxicity.