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Methotrexate and cyclosporin

Although cyclosporin has been combined with a number of drugs, including gold and Hydroxychloroquine, the only proven effective combination is with methotrexate. A key trial from the 1990s, led by Peter Tugwell, showed that in patients with an incomplete response to methotrexate adding cyclosporin improved joint counts and global assessments over six months.
This benefit was also sustained for one year.